Title : ATM inhibitor KU-55933 induces apoptosis and inhibits motility by blocking GLUT1-mediated glucose uptake in aggressive cancer cells with sustained activation of Akt.

Pub. Date : 2021 Apr

PMID : 33715230






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 ATM inhibitor KU-55933 induces apoptosis and inhibits motility by blocking GLUT1-mediated glucose uptake in aggressive cancer cells with sustained activation of Akt. Glucose solute carrier family 2 (facilitated glucose transporter), member 1 Mus musculus
2 These results suggest that ATM acts as a promoter of tumorigenesis in cancer cells with overactivated Akt, and KU-55933 induces apoptosis and inhibits motility by blocking GLUT1-mediated glucose uptake and glycolysis in these cancer cells, which may lead to the use of KU-55933 and its analogs as new preventive or therapeutic agents against cancer. Glucose solute carrier family 2 (facilitated glucose transporter), member 1 Mus musculus