Pub. Date : 2021 Apr 27
PMID : 33677506
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Particulate Cr(VI) causes DNA double strand breaks and prolonged exposure impairs homologous recombination targeting a key effector protein in this pathway, RAD51. | chromium hexavalent ion | RAD51 recombinase | Homo sapiens |
| 2 | Reduced RAD51 protein is a key endpoint of particulate Cr(VI) exposure. | chromium hexavalent ion | RAD51 recombinase | Homo sapiens |
| 3 | It is currently unknown how Cr(VI) reduces RAD51 protein. | chromium hexavalent ion | RAD51 recombinase | Homo sapiens |
| 4 | This study sought to identify if E2F1 modulates the RAD51 response to particulate Cr(VI). | chromium hexavalent ion | RAD51 recombinase | Homo sapiens |
| 5 | Particulate Cr(VI) reduced RAD51 protein and mRNA levels but had a minimal effect on RAD51 half-life. | chromium hexavalent ion | RAD51 recombinase | Homo sapiens |
| 6 | E2F1 knockdown inhibited RAD51 nuclear foci formation after acute particulate Cr(VI) exposure. | chromium hexavalent ion | RAD51 recombinase | Homo sapiens |
| 7 | These data indicate reduced RAD51 protein levels after prolonged particulate Cr(VI) exposure are predominantly due to inhibited expression. | chromium hexavalent ion | RAD51 recombinase | Homo sapiens |