Title : An effective human uracil-DNA glycosylase inhibitor targets the open pre-catalytic active site conformation.

Pub. Date : 2021 Aug

PMID : 33675849






1 Functional Relationships(s)
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1 UDG depletion sensitizes cells to high APOBEC3B deaminase and to pemetrexed (PEM) and floxuridine (5-FdU), which are toxic to tumor cells through incorporation of uracil and 5-FU into DNA. Floxuridine uracil DNA glycosylase Homo sapiens