Title : Small-Angle X-ray Scattering Models of APOBEC3B Catalytic Domain in a Complex with a Single-Stranded DNA Inhibitor.

Pub. Date : 2021 Feb 12

PMID : 33673243






1 Functional Relationships(s)
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1 We present models based on small-angle X-ray scattering (SAXS) data that (1) confirm that the mode of binding of inhibitor to an active A3B C-terminal domain construct in the solution state is the same as the mode of binding substrate to inactive mutants of A3A and A3B revealed in X-ray crystal structures and (2) give insight into the disulfide-linked inactive dimer formed under the oxidizing conditions of purification. Disulfides apolipoprotein B mRNA editing enzyme catalytic subunit 3B Homo sapiens