Title : Pharmacological Activation of p53 during Human Monocyte to Macrophage Differentiation Attenuates Their Pro-Inflammatory Activation by TLR4, TLR7 and TLR8 Agonists.

Pub. Date : 2021 Feb 25

PMID : 33668835






2 Functional Relationships(s)
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Protein Name
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1 However, when present during monocyte to macrophage differentiation, idasanutlin attenuated inflammatory responses towards activation of TLR4 and TLR7/8 by low doses of lipopolysaccharide or resiquimod (R848). RG7388 toll like receptor 7 Homo sapiens
2 This was accompanied by a reduced expression of CD14, TLR7, and TLR8 in macrophages differentiated in the presence of idasanutlin. RG7388 toll like receptor 7 Homo sapiens