Title : SUMOylation promotes extracellular vesicle-mediated transmission of lncRNA ELNAT1 and lymph node metastasis in bladder cancer.

Pub. Date : 2021 Apr 15

PMID : 33661764






1 Functional Relationships(s)
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1 Mechanistically, ELNAT1 induced UBC9 overexpression to catalyze the SUMOylation of hnRNPA1 at lysine-113 residue, which mediated the recognition of ELNAT1 by endosomal sorting complex required for transport (ESCRT) and facilitated their packaging into EVs. Lysine ubiquitin conjugating enzyme E2 I Homo sapiens