Title : Long noncoding RNA XIST enhances cerebral ischemia-reperfusion injury by regulating miR-486-5p and GAB2.

Pub. Date : 2021 Feb

PMID : 33660813






3 Functional Relationships(s)
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1 For our experiment, miR-486-5p was a target of XIST, and GAB2 was a downstream gene of miR-486-5p. mir-486-5p X inactive specific transcript Homo sapiens
2 Furthermore, miR-486-5p mimic promoted cell proliferation and inhibited cell apoptosis, while XIST co-transfection reversed the effect of miR-486-5p. mir-486-5p X inactive specific transcript Homo sapiens
3 In addition, XIST was found to impair the inhibitory effect of miR-486-5p on expression of GAB2 in I/R cells. mir-486-5p X inactive specific transcript Homo sapiens