Title : Impact of Methyl-β-Cyclodextrin and Apolipoprotein A-I on The Expression of ATP-Binding Cassette Transporter A1 and Cholesterol Depletion in C57BL/6 Mice Astrocytes.

Pub. Date : 2021 Apr

PMID : 33650825






5 Functional Relationships(s)
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1 Here, we have investigated whether cyclodextrin (CD) and apolipoprotein A-I (apoA-I) induce the same signal to inhibit cell cholesterol accumulation by focusing on the main proteins involved in cholesterol homeostasis in response to CD and apoA-I treatment. Cholesterol apolipoprotein A-I Mus musculus
2 Here, we have investigated whether cyclodextrin (CD) and apolipoprotein A-I (apoA-I) induce the same signal to inhibit cell cholesterol accumulation by focusing on the main proteins involved in cholesterol homeostasis in response to CD and apoA-I treatment. Cholesterol apolipoprotein A-I Mus musculus
3 Both apoA-I and CD increased cholesterol release in the medium. Cholesterol apolipoprotein A-I Mus musculus
4 Conclusion: CD, like apoA-I, depletes cellular cholesterol. Cholesterol apolipoprotein A-I Mus musculus
5 This depletion occurs in a different way from apoA-I that is through cholesterol efflux. Cholesterol apolipoprotein A-I Mus musculus