Title : Zymogen-locked mutant prostasin (Prss8) leads to incomplete proteolytic activation of the epithelial sodium channel (ENaC) and severely compromises triamterene tolerance in mice.

Pub. Date : 2021 May

PMID : 33650216






2 Functional Relationships(s)
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1 Zymogen-locked mutant prostasin (Prss8) leads to incomplete proteolytic activation of the epithelial sodium channel (ENaC) and severely compromises triamterene tolerance in mice. Sodium sodium channel, nonvoltage-gated 1 alpha Mus musculus
2 AIM: The serine protease prostasin (Prss8) is expressed in the distal tubule and stimulates proteolytic activation of the epithelial sodium channel (ENaC) in co-expression experiments in vitro. Sodium sodium channel, nonvoltage-gated 1 alpha Mus musculus