Title : Lipid nanoparticle-mediated codelivery of Cas9 mRNA and single-guide RNA achieves liver-specific in vivo genome editing of Angptl3.

Pub. Date : 2021 Mar 9

PMID : 33649229






1 Functional Relationships(s)
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1 This system mediated specific and efficient Angptl3 gene knockdown in the liver of wild-type C57BL/6 mice, resulting in profound reductions in serum ANGPTL3 protein, low density lipoprotein cholesterol, and triglyceride levels. Triglycerides angiopoietin-like 3 Mus musculus