Title : Pulsed electromagnetic fields synergize with graphene to enhance dental pulp stem cell-derived neurogenesis by selectively targeting TRPC1 channels.

Pub. Date : 2021 Mar 1

PMID : 33644848






3 Functional Relationships(s)
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1 As brief PEMF exposure promotes in vitro differentiation by activating a TRPC1-mitochondrial axis, an opportunity to combine 2DG with developmentally targeted PEMF exposure for synergistic effects was realizable. pemf transient receptor potential cation channel subfamily C member 1 Homo sapiens
2 Neurogenic gene expression, neurotransmitter release, and reactive oxygen species (ROS) production were greatly enhanced by a brief (10 min) and low amplitude (2 mT) PEMF exposure timed to coincide with the highest TRPC1 expression from hDPSCs on 2DG. pemf transient receptor potential cation channel subfamily C member 1 Homo sapiens
3 Hence, graphene created a more conducive environment for subsequent PEMF-stimulated neurogenic induction of hDPSCs through their mutual capacity to activate TRPC1with subsequent ROS production. pemf transient receptor potential cation channel subfamily C member 1 Homo sapiens