Pub. Date : 2021 Feb 27
PMID : 33640015
5 Functional Relationships(s)Download |
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Sentence | Compound Name | Protein Name | Organism |
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| 1 | To identify the necessary cell signaling proteins in E2-induced TGFbeta1 and TGFbeta2 transcription, human dermal fibroblasts were pre-treated with an inhibitor of the extracellular signal-regulated kinase/mitogen-activated protein kinase (ERK/MAPK) pathway, U0126. | Estradiol | transforming growth factor beta 1 | Homo sapiens | ||
| 2 | RESULTS: We found that expression of TGFbeta1, TGFbeta2, and Col22A1, a TGFbeta-responsive gene, is induced in response to E2 stimulation. | Estradiol | transforming growth factor beta 1 | Homo sapiens | ||
| 3 | Additionally, inhibiting E2-induced ERK/MAPK activation and early growth response 1 (EGR1) transcription prevents the E2-induced increase in TGFbeta1 and TGFbeta2 transcription and translation. | Estradiol | transforming growth factor beta 1 | Homo sapiens | ||
| 4 | Additionally, inhibiting E2-induced ERK/MAPK activation and early growth response 1 (EGR1) transcription prevents the E2-induced increase in TGFbeta1 and TGFbeta2 transcription and translation. | Estradiol | transforming growth factor beta 1 | Homo sapiens | ||
| 5 | CONCLUSIONS: We conclude that E2-induced dermal fibrosis occurs in part through induction of TGFbeta1, 2, and Col22A1, which is regulated through EGR1 and the MAPK pathway. | Estradiol | transforming growth factor beta 1 | Homo sapiens | ||