Pub. Date : 2021 Apr 9
PMID : 33631669
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The disuccinimidyl suberate (DSS) cross-linking assay and immunological analyses indicated that exposure of several types of cells to 6-OHDA resulted in BAX activation and subsequent oligomerization. | Oxidopamine | BCL2 associated X, apoptosis regulator | Homo sapiens |
| 2 | Pharmacological inhibition and genetic perturbation of autophagy prevented 6-OHDA-induced BAX oligomerization and subsequent release of mitochondrial cytochrome c into the cytosol and caspase activation. | Oxidopamine | BCL2 associated X, apoptosis regulator | Homo sapiens |
| 3 | Taken together, our results suggest that BAX oligomerization comprises a critical step by which 6-OHDA-induced dysregulated autophagy mediates neuronal apoptosis. | Oxidopamine | BCL2 associated X, apoptosis regulator | Homo sapiens |