Title : Reduction of Neuroinflammation by δ-Opioids Via STAT3-Dependent Pathway in Chronic Glaucoma Model.

Pub. Date : 2021

PMID : 33628191






2 Functional Relationships(s)
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1 Mechanistically, we provide data showing a significant increase in the phosphorylation of STAT3 at tyrosine 705 whereas a moderate but significant increase in the total STAT3 protein expression was also seen in the retina of ocular hypertensive animals. Tyrosine signal transducer and activator of transcription 3 Rattus norvegicus
2 In conclusion, delta-opioid receptor activation suppressed the phosphorylation of STAT3 at tyrosine 705 and increased acetylation at lysine 686 and these posttranslational modifications can regulate the production of some but not all pro-inflammatory cytokines in response to glaucomatous injury. Tyrosine signal transducer and activator of transcription 3 Rattus norvegicus