Title : DNA primase subunit 1 deteriorated progression of hepatocellular carcinoma by activating AKT/mTOR signaling and UBE2C-mediated P53 ubiquitination.

Pub. Date : 2021 Feb 23

PMID : 33622397






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Overexpression of PRIM1 promoted the proliferation, migration/invasion, and sorafenib resistance of HCC cells, with the decrease in apoptosis and cell cycle arrest. Sorafenib DNA primase subunit 1 Homo sapiens
2 Furthermore, knockdown of PRIM1 significantly inhibited the growth of xenograft tumors and HCC cells-derived spheroids with enhanced sorafenib resistance. Sorafenib DNA primase subunit 1 Homo sapiens