Title : Longitudinal and multi-tissue molecular diagnostics track somatic BRCA2 reversion mutations that correct the open reading frame of germline alteration upon clinical relapse.

Pub. Date : 2021 Feb 22

PMID : 33619265






1 Functional Relationships(s)
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1 Two unique BRCA2 somatic alterations (p.N255fs and p.D252fs) were identified upon resistance to PARP inhibitor and platinum treatment, respectively. Platinum BRCA2 DNA repair associated Homo sapiens