Title : TIA1 potentiates tau phase separation and promotes generation of toxic oligomeric tau.

Pub. Date : 2021 Mar 2

PMID : 33619090






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Here we show that the interaction of tau with RNA and the RNA binding protein TIA1 is sufficient to drive phase separation of tau at physiological concentrations, without the requirement for artificial crowding agents such as polyethylene glycol (PEG). Polyethylene Glycols TIA1 cytotoxic granule associated RNA binding protein Homo sapiens
2 Here we show that the interaction of tau with RNA and the RNA binding protein TIA1 is sufficient to drive phase separation of tau at physiological concentrations, without the requirement for artificial crowding agents such as polyethylene glycol (PEG). Polyethylene Glycols TIA1 cytotoxic granule associated RNA binding protein Homo sapiens