Title : Orexin-A/Hypocretin-1 Controls the VTA-NAc Mesolimbic Pathway via Endocannabinoid-Mediated Disinhibition of Dopaminergic Neurons in Obese Mice.

Pub. Date : 2021

PMID : 33613258






1 Functional Relationships(s)
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1 Enhanced DA signaling to the NAc in ob/ob mice, or in OX-A-injected wt mice, was accompanied by beta-arrestin2-mediated desensitization of dopamine D2 receptor (D2R) in a manner prevented by SB-334867 or the D2R antagonist L741 (1.5 mg/Kg, i.p.). 1-(2-methylbenzoxazol-6-yl)-3-(1,5)naphthyridin-4-yl urea arrestin, beta 2 Mus musculus