Pub. Date : 2021 Apr 15
PMID : 33610598
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Low anticoagulant heparin-iron complex targeting inhibition of hepcidin ameliorates anemia of chronic disease in rodents. | Iron | hepcidin antimicrobial peptide | Mus musculus |
| 2 | Hepcidin is the only known hormone negatively regulates systemic iron availability, its excess contributes to anemia of chronic disease (ACD).Heparin has been shown to be an efficient hepcidin inhibitor both in vitro and in vivo, but its powerful anticoagulant activity limits this therapeutic application. | Iron | hepcidin antimicrobial peptide | Mus musculus |
| 3 | Hepcidin is the only known hormone negatively regulates systemic iron availability, its excess contributes to anemia of chronic disease (ACD).Heparin has been shown to be an efficient hepcidin inhibitor both in vitro and in vivo, but its powerful anticoagulant activity limits this therapeutic application. | Iron | hepcidin antimicrobial peptide | Mus musculus |
| 4 | Heparin-iron was also found to cause a reduction on hepcidin expression through BMP/SMAD and JAK/STAT3 pathways in LPS induced acute inflammation model in mice. | Iron | hepcidin antimicrobial peptide | Mus musculus |
| 5 | In ACD mice, heparin-iron could lower elevated serum hepcidin and improve anemia. | Iron | hepcidin antimicrobial peptide | Mus musculus |
| 6 | These findings demonstrated low anticoagulant heparin-iron has potential applications for the treatment of ACD with high hepcidin levels. | Iron | hepcidin antimicrobial peptide | Mus musculus |