Title : Involvement of TCF7L2 in generation of morphine-induced antinociceptive tolerance and hyperalgesia by modulating TLR4/ NF-κB/NLRP3 in microglia.

Pub. Date : 2021 Apr 1

PMID : 33607128






3 Functional Relationships(s)
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1 Involvement of TCF7L2 in generation of morphine-induced antinociceptive tolerance and hyperalgesia by modulating TLR4/ NF-kappaB/NLRP3 in microglia. Morphine NLR family pyrin domain containing 3 Homo sapiens
2 In this study, we found that morphine tolerance led to the upregulation of TCF7L2 in the spinal cord, and also led to the upregulation of TCF7L2 expression in glial cells, which promoted inflammation related signal, and activated TLR4 / NF-kappaB/NLRP3 pathway. Morphine NLR family pyrin domain containing 3 Homo sapiens
3 We therefore suggested that TCF7L2 regulates the activation of TLR4/ NF-kappaB/NLRP3 pathway in microglia, and is involved in the formation of morphine tolerance. Morphine NLR family pyrin domain containing 3 Homo sapiens