Title : IL-17-induced inflammation modulates the mPGES-1/PPAR-γ pathway in monocytes/macrophages.

Pub. Date : 2022 May

PMID : 33595097






1 Functional Relationships(s)
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1 BACKGROUND AND PURPOSE: Recent biochemical and pharmacological studies have reported that in several tissues and cell types, microsomal prostaglandin E2 synthase (mPGES) and peroxisome proliferator-activated receptor-gamma (PPAR-gamma) expression are modulated by a variety of inflammatory factors and stimuli Considering that very little is known about the biological effects promoted by IL-17 in the context of mPGES-1/PPAR-gamma modulation, we sought to investigate the contribution of this unique cytokine on this integrated pathway during the onset of inflammation. Dinoprostone prostaglandin E synthase Mus musculus