Title : A synergy of estradiol with leptin modulates the long non-coding RNA NEAT1/ mmu-miR-204-5p/IGF1 axis in the uterus of high-fat-diet-induced obese ovariectomized mice.

Pub. Date : 2021 May

PMID : 33588025






3 Functional Relationships(s)
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1 A synergy of estradiol with leptin modulates the long non-coding RNA NEAT1/ mmu-miR-204-5p/IGF1 axis in the uterus of high-fat-diet-induced obese ovariectomized mice. Estradiol nuclear paraspeckle assembly transcript 1 (non-protein coding) Mus musculus
2 The decreased expression of mmu- miR-204-5p after estradiol and leptin treatments correlated with the increased expression of long non-coding RNA Neat1. Estradiol nuclear paraspeckle assembly transcript 1 (non-protein coding) Mus musculus
3 Overall, the data from our in vivo studies suggest the regulation of Neat1-mmu-miR-204-5p- Igf1 axis and associated gene expression changes in uterine tissue after estradiol and leptin co-treatment. Estradiol nuclear paraspeckle assembly transcript 1 (non-protein coding) Mus musculus