Title : Carbonyl reduction pathway in hepatic in vitro metabolism of anthracyclines: Impact of structure on biotransformation rate.

Pub. Date : 2021 May 15

PMID : 33581289






3 Functional Relationships(s)
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1 Significant differences of intrinsic clearance between anthracyclines, ranging from 0,62 to 74,9 microl/min/mg were found and associated with data from in silico analyses, considering their binding in active sites of the main anthracyclines-reducing enzymes: carbonyl reductase 1 (CBR1) and aldo-keto reductase 1C3 (AKR1C3). Anthracyclines carbonyl reductase 1 Homo sapiens
2 Significant differences of intrinsic clearance between anthracyclines, ranging from 0,62 to 74,9 microl/min/mg were found and associated with data from in silico analyses, considering their binding in active sites of the main anthracyclines-reducing enzymes: carbonyl reductase 1 (CBR1) and aldo-keto reductase 1C3 (AKR1C3). Anthracyclines carbonyl reductase 1 Homo sapiens
3 Significant differences of intrinsic clearance between anthracyclines, ranging from 0,62 to 74,9 microl/min/mg were found and associated with data from in silico analyses, considering their binding in active sites of the main anthracyclines-reducing enzymes: carbonyl reductase 1 (CBR1) and aldo-keto reductase 1C3 (AKR1C3). Anthracyclines carbonyl reductase 1 Homo sapiens