Title : siRNAs containing 2'-fluorinated Northern-methanocarbacyclic (2'-F-NMC) nucleotides: in vitro and in vivo RNAi activity and inability of mitochondrial polymerases to incorporate 2'-F-NMC NTPs.

Pub. Date : 2021 Mar 18

PMID : 33577685






1 Functional Relationships(s)
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1 The steric constraints of the bicyclic 2"-F-NMC may impair formation of hydrogen-bonding interactions between the vinylphosphonate and the MID domain of Ago2. 2"-f-nmc argonaute RISC catalytic subunit 2 Mus musculus