Title : Investigation of the aquaporin-2 gating mechanism with molecular dynamics simulations.

Pub. Date : 2021 Jul

PMID : 33576101






3 Functional Relationships(s)
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1 Aquaporin-2 plays a vital role in the human kidney as a water passage channel. Water aquaporin 2 Homo sapiens
2 Moreover, by calculating the osmotic permeability and the potential of mean force (PMF) of each of the AQP2 monomers for wide/narrow states of the SF, it is seen that the selectivity filter at its narrow conformation can induce a much larger energy barrier for water molecules permeation, hindering the transport of water molecules remarkably. Water aquaporin 2 Homo sapiens
3 Moreover, by calculating the osmotic permeability and the potential of mean force (PMF) of each of the AQP2 monomers for wide/narrow states of the SF, it is seen that the selectivity filter at its narrow conformation can induce a much larger energy barrier for water molecules permeation, hindering the transport of water molecules remarkably. Water aquaporin 2 Homo sapiens