Title : In Silico Study of Polyunsaturated Fatty Acids as Potential SARS-CoV-2 Spike Protein Closed Conformation Stabilizers: Epidemiological and Computational Approaches.

Pub. Date : 2021 Jan 29

PMID : 33573088






2 Functional Relationships(s)
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1 Moreover, it was found that linoleic acid, an omega-6 PUFA, could stabilize the spike protein in a closed conformation, blocking its interaction with ACE2. Linoleic Acid surface glycoprotein Severe acute respiratory syndrome coronavirus 2
2 We found that: (a) countries whose source of omega-3 is from marine origin have lower fatality rates; and (b) like linoleic acid, omega-3 PUFA could also bind to the closed conformation of spike protein and therefore, could help reduce COVID-19 complications by reducing viral entrance to cells, in addition to their known anti-inflammatory effects. Linoleic Acid surface glycoprotein Severe acute respiratory syndrome coronavirus 2