Title : Cutting Edge of the Pathogenesis of Atopic Dermatitis: Sphingomyelin Deacylase, the Enzyme Involved in Its Ceramide Deficiency, Plays a Pivotal Role.

Pub. Date : 2021 Feb 5

PMID : 33562655






1 Functional Relationships(s)
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Protein Name
Organism
1 SM deacylase competes with aSMase and beta-glucocerebrosidase (BGCase) to hydrolyze their common substrates, SM and GCer, to yield their lysoforms sphingosylphosphorylcholine (SPC) and glucosylsphingosine (GSP), respectively, instead of ceramide. Glucosylceramides sphingomyelin phosphodiesterase 1 Homo sapiens