Title : Camptothecin and Topotecan, Inhibitors of Transcription Factor Fli-1 and Topoisomerase, Markedly Ameliorate Lupus Nephritis in (NZB × NZW)F1 Mice and Reduce the Production of Inflammatory Mediators in Human Renal Cells.

Pub. Date : 2021 Aug

PMID : 33559345






2 Functional Relationships(s)
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1 Camptothecin and topotecan, inhibitors of transcription factor Fli-1 and topoisomerase, markedly ameliorate lupus nephritis in NZBWF1 mice and reduce the production of inflammatory mediators in human renal cells. Camptothecin WD repeat and FYVE domain containing 3 Mus musculus
2 OBJECTIVE: To examine the therapeutic effects of camptothecin (CPT) and topotecan (TPT), inhibitors of transcription factor Fli-1 and topoisomerase, on lupus nephritis in NZBWF1 mice and their effects on inflammatory mediators in human renal cells. Camptothecin WD repeat and FYVE domain containing 3 Mus musculus