Pub. Date : 2021 Jan
PMID : 33553331
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | miR-126-3p contributes to sorafenib resistance in hepatocellular carcinoma via downregulating SPRED1. | Sorafenib | microRNA 1263 | Homo sapiens |
| 2 | Results: HCC cells with high expression of miR-126-3p exhibited increased resistance to sorafenib. | Sorafenib | microRNA 1263 | Homo sapiens |
| 3 | Gain- and loss-of function experiments verified that miR-126-3p induced sorafenib resistance in HCC through downregulating SPRED1. | Sorafenib | microRNA 1263 | Homo sapiens |
| 4 | Furthermore, the inhibition of miR-126-3p markedly increased the effectiveness of sorafenib against HCC in vivo. | Sorafenib | microRNA 1263 | Homo sapiens |
| 5 | Mechanistically, our results suggested that miR-126-3p promoted sorafenib resistance via targeting SPRED1 and activating the ERK signaling pathway. | Sorafenib | microRNA 1263 | Homo sapiens |
| 6 | Conclusions: Our study demonstrates that regulating the miR-126-3p/SPRED1 axis might be a promising strategy for enhancing the antitumor effect of sorafenib in the treatment of HCC. | Sorafenib | microRNA 1263 | Homo sapiens |