Title : Structural analysis of COVID-19 spike protein in recognizing the ACE2 receptor of different mammalian species and its susceptibility to viral infection.

Pub. Date : 2021 Feb

PMID : 33552834






1 Functional Relationships(s)
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1 Our comprehensive structure analysis revealed that the natural substitution of amino acid residues Gln24, His34, Phe40, Leu79 and Met82 in the N-terminal alpha1 and alpha2 helices of the ACE2 receptor results in loss of crucial network of hydrogen-bonded and hydrophobic interactions with receptor binding domain of SARS-CoV-2 spike protein. Hydrogen surface glycoprotein Severe acute respiratory syndrome coronavirus 2