Title : Multiomics-Identified Intervention to Restore Ethanol-Induced Dysregulated Proteostasis and Secondary Sarcopenia in Alcoholic Liver Disease.

Pub. Date : 2021 Feb 6

PMID : 33543862






2 Functional Relationships(s)
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1 RESULTS: Multiomics analyses showed that ethanol impaired skeletal muscle mTORC1 signaling, mitochondrial oxidative pathways, including intermediary metabolite regulatory genes, interleukin-6, and amino acid degradation pathways are beta-hydroxymethyl-butyrate targets. Ethanol CREB regulated transcription coactivator 1 Mus musculus
2 Ethanol decreased mTORC1 signaling, increased autophagy flux, impaired mitochondrial oxidative function with decreased tricarboxylic acid cycle intermediary metabolites, ATP synthesis, protein synthesis and myotube diameter that were reversed by HMB. Ethanol CREB regulated transcription coactivator 1 Mus musculus