Title : Metformin: a novel promising option for fertility preservation during cyclophosphamide-based chemotherapy.

Pub. Date : 2021 Jan 22

PMID : 33543290






1 Functional Relationships(s)
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1 In in-vitro granulosa cell experiments, the anti-apoptotic effect of metformin was blocked after inhibiting p53 or p21 function, and the expression of p53 mRNA was blocked with AMPK inhibitor, suggesting that the anti-apoptotic effect was AMPK/p53/p21-mediated. Metformin transformation related protein 53, pseudogene Mus musculus