Title : A Phase I dose-escalation study of two cycles carboplatin-olaparib followed by olaparib monotherapy in patients with advanced cancer.

Pub. Date : 2021 Jun 15

PMID : 33539540






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1 Preclinical studies have shown synergistic effects when combining PARP1/2-inhibitors and platinum drugs in BRCA1/2 mutated cancer cell models. Platinum BRCA1 DNA repair associated Homo sapiens