Title : Development of Novel Rhodacyanine-Based Heat Shock Protein 70 Inhibitors.

Pub. Date : 2021

PMID : 33538660






2 Functional Relationships(s)
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1 METHOD: We developed a new series of rhodacyanine-based Hsp70 inhibitors, represented by compounds 1 and 6, in which the cationic pyridin-1-ium or thiazol-3-ium ring of existing Hsp70 inhibitors (e.g., JG-40 and JG-98) was replaced by a corresponding benzo-fused N-heterocycle. pyridine heat shock protein family A (Hsp70) member 4 Homo sapiens
2 METHOD: We developed a new series of rhodacyanine-based Hsp70 inhibitors, represented by compounds 1 and 6, in which the cationic pyridin-1-ium or thiazol-3-ium ring of existing Hsp70 inhibitors (e.g., JG-40 and JG-98) was replaced by a corresponding benzo-fused N-heterocycle. pyridine heat shock protein family A (Hsp70) member 4 Homo sapiens