Title : SARS-CoV-2 recruits a haem metabolite to evade antibody immunity.

Pub. Date : 2021 Jan 26

PMID : 33532784






2 Functional Relationships(s)
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1 We show that SARS-CoV-2 spike binds biliverdin and bilirubin, the tetrapyrrole products of haem metabolism, with nanomolar affinity. Tetrapyrroles surface glycoprotein Severe acute respiratory syndrome coronavirus 2
2 Using cryo-electron microscopy and X-ray crystallography we mapped the tetrapyrrole interaction pocket to a deep cleft on the spike N-terminal domain (NTD). Tetrapyrroles surface glycoprotein Severe acute respiratory syndrome coronavirus 2