Title : Epigenetic suppression of SLFN11 in germinal center B-cells during B-cell development.

Pub. Date : 2021

PMID : 33513156






5 Functional Relationships(s)
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1 We also examined the therapeutic efficacy of these drugs in combination with cytosine arabinoside and the effects of SLFN11 on the efficacy of cytosine arabinoside in SLFN11-overexpressing cells. Cytarabine schlafen family member 11 Homo sapiens
2 We also examined the therapeutic efficacy of these drugs in combination with cytosine arabinoside and the effects of SLFN11 on the efficacy of cytosine arabinoside in SLFN11-overexpressing cells. Cytarabine schlafen family member 11 Homo sapiens
3 The EZH2 and HDAC epigenetic modifiers upregulated SLFN11 expression in GCB-derived lymphoma cells and made them more susceptible to cytosine arabinoside. Cytarabine schlafen family member 11 Homo sapiens
4 SLFN11 overexpression further sensitized GCB-derived lymphoma cells to cytosine arabinoside. Cytarabine schlafen family member 11 Homo sapiens
5 GCB-derived lymphomas with low SLFN11 expression can be treated by the combination of epigenetic modifiers and cytosine arabinoside. Cytarabine schlafen family member 11 Homo sapiens