Title : Selective Inhibition of 2-Oxoglutarate and 2-Oxoadipate Dehydrogenases by the Phosphonate Analogs of Their 2-Oxo Acid Substrates.

Pub. Date : 2020

PMID : 33511099






1 Functional Relationships(s)
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1 The consistent kinetic and structural results expose adipoyl phosphonate as a valuable pharmacological tool for specific in vivo inhibition of the DHTKD1-encoded OADH, a new member of mammalian family of 2-oxo acid dehydrogenases, up-regulated in some cancers and associated with diabetes and obesity. adipoyl phosphonate dehydrogenase E1 and transketolase domain containing 1 Homo sapiens