Title : Kinase inhibitors allosterically disrupt a regulatory interaction to enhance PKCα membrane translocation.

Pub. Date : 2021 Jan-Jun

PMID : 33508318






1 Functional Relationships(s)
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1 SMKI-mediated displacement of the Gly-rich loop released C1a and exposed the DAG binding site, enhancing PKCalpha translocation both to synthetic lipid bilayers and to live cell membranes in the presence of DAG. Lipid Bilayers protein kinase C alpha Homo sapiens