Title : Protective Role of Natural and Semi-Synthetic Tocopherols on TNFα-Induced ROS Production and ICAM-1 and Cl-2 Expression in HT29 Intestinal Epithelial Cells.

Pub. Date : 2021 Jan 22

PMID : 33499140






3 Functional Relationships(s)
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1 Protective Role of Natural and Semi-Synthetic Tocopherols on TNFalpha-Induced ROS Production and ICAM-1 and Cl-2 Expression in HT29 Intestinal Epithelial Cells. Tocopherols tumor necrosis factor Homo sapiens
2 The results show that all tocopherol containing derivatives used, prevented TNFalpha-induced oxidative stress and the increase of ICAM-1 and Cl-2 expression, and that (delta-Toc)2S and (delta-Toc)2S2 are more effective than delta-Toc and alpha-Toc. Tocopherols tumor necrosis factor Homo sapiens
3 Since ICAM-1 and Cl-2 increase intestinal bowel diseases, and cause excessive recruitment of immune cells and alteration of the intestinal barrier, natural and, above all, semi-synthetic tocopherols may have a potential role as a therapeutic support against intestinal chronic inflammation, in which TNFalpha represents an important proinflammatory mediator. Tocopherols tumor necrosis factor Homo sapiens