Title : 17β-Estradiol and estrogen receptor α protect right ventricular function in pulmonary hypertension via BMPR2 and apelin.

Pub. Date : 2021 Mar 15

PMID : 33497359






4 Functional Relationships(s)
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1 We hypothesized that 17beta-estradiol (E2), through estrogen receptor alpha (ERalpha), attenuates PAH-induced RV failure (RVF) by up-regulating the pro-contractile and pro-survival peptide apelin via a bone morphogenetic protein receptor 2 (BMPR2)-dependent mechanism. Estradiol estrogen receptor 1 Homo sapiens
2 We hypothesized that 17beta-estradiol (E2), through estrogen receptor alpha (ERalpha), attenuates PAH-induced RV failure (RVF) by up-regulating the pro-contractile and pro-survival peptide apelin via a bone morphogenetic protein receptor 2 (BMPR2)-dependent mechanism. Estradiol estrogen receptor 1 Homo sapiens
3 We hypothesized that 17beta-estradiol (E2), through estrogen receptor alpha (ERalpha), attenuates PAH-induced RV failure (RVF) by up-regulating the pro-contractile and pro-survival peptide apelin via a bone morphogenetic protein receptor 2 (BMPR2)-dependent mechanism. Estradiol estrogen receptor 1 Homo sapiens
4 We hypothesized that 17beta-estradiol (E2), through estrogen receptor alpha (ERalpha), attenuates PAH-induced RV failure (RVF) by up-regulating the pro-contractile and pro-survival peptide apelin via a bone morphogenetic protein receptor 2 (BMPR2)-dependent mechanism. Estradiol estrogen receptor 1 Homo sapiens