Pub. Date : 2021 Jan 22
PMID : 33490900
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Hydroxychloroquine can impair tumor response to anti-PD1 in subcutaneous mouse models. | Hydroxychloroquine | programmed cell death 1 | Mus musculus |
| 2 | Here, we evaluate the influence of HCQ treatment on the effect of anti-PD1 tumor immunotherapy. | Hydroxychloroquine | programmed cell death 1 | Mus musculus |
| 3 | Anti-PD1 therapy-sensitive tumor lines MC38, CT26, and RIL-175 were used to investigate the impact of HCQ on anti-PD1 therapy efficacy. | Hydroxychloroquine | programmed cell death 1 | Mus musculus |
| 4 | Importantly, in all the three tumor models, HCQ treatment significantly impaired the response to anti-PD1 treatment, accompanying diminished in vivo T-cell activation and reduced tumor-infiltrating, antigen-specific CD8+ T cells. | Hydroxychloroquine | programmed cell death 1 | Mus musculus |