Title : Alternate therapeutic pathways for PARP inhibitors and potential mechanisms of resistance.

Pub. Date : 2021 Jan

PMID : 33487630






2 Functional Relationships(s)
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1 For example, somatic BRCA1/2 reversion mutations are often identified in patients with BRCA1/2-mutated cancers after treatment with platinum-based therapy, causing restoration of HR capacity and thus conferring PARPi resistance. Platinum BRCA1 DNA repair associated Homo sapiens
2 For example, somatic BRCA1/2 reversion mutations are often identified in patients with BRCA1/2-mutated cancers after treatment with platinum-based therapy, causing restoration of HR capacity and thus conferring PARPi resistance. Platinum BRCA1 DNA repair associated Homo sapiens