Pub. Date : 2021 Jan 11
PMID : 33486250
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We hypothesized that curcumin attenuates fluoride toxicity through modulation of Ac-p53. | Curcumin | tumor protein p53 | Homo sapiens |
| 2 | Here we investigated how curcumin affects the p53-p21 pathway in fluoride toxicity. | Curcumin | tumor protein p53 | Homo sapiens |
| 3 | However, curcumin itself significantly increased Ac-p53 and upregulated p21 protein levels to suppress cell proliferation in a dose-dependent manner. | Curcumin | tumor protein p53 | Homo sapiens |
| 4 | These results suggest that curcumin-induced Ac-p53 and p21 led to cell cycle arrest, while curcumin attenuated fluoride-mediated apoptosis via activation of Akt and suppressed fluoride-mediated DNA damage. | Curcumin | tumor protein p53 | Homo sapiens |