Pub. Date : 2021 Sep 28
PMID : 33483749
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | AIMS: Gp91-containing NADPH oxidases (NOX2) are a significant source of myocardial superoxide production. | Superoxides | cytochrome b-245, beta polypeptide | Mus musculus |
| 2 | METHODS AND RESULTS: NOX2-Tg mice showed a 2-2.5-fold higher atrial protein content of NOX2 compared with wild-type (WT) controls, which was associated with a significant (2-fold) increase in NADPH-stimulated superoxide production (2-hydroxyethidium by HPLC) in left and right atrial tissue homogenates (P = 0.004 and P = 0.019, respectively). | Superoxides | cytochrome b-245, beta polypeptide | Mus musculus |
| 3 | METHODS AND RESULTS: NOX2-Tg mice showed a 2-2.5-fold higher atrial protein content of NOX2 compared with wild-type (WT) controls, which was associated with a significant (2-fold) increase in NADPH-stimulated superoxide production (2-hydroxyethidium by HPLC) in left and right atrial tissue homogenates (P = 0.004 and P = 0.019, respectively). | Superoxides | cytochrome b-245, beta polypeptide | Mus musculus |
| 4 | Finally, treatment with atorvastatin significantly inhibited atrial superoxide production in NOX2-Tg but had no effect on AF induction in either genotype. | Superoxides | cytochrome b-245, beta polypeptide | Mus musculus |
| 5 | CONCLUSIONS: Together, these data indicate that whilst atrial NOX2 overexpression may contribute to atrial arrhythmogenesis, NOX2-derived superoxide production does not affect the electrical and structural properties of the atrial myocardium. | Superoxides | cytochrome b-245, beta polypeptide | Mus musculus |
| 6 | Short-term treatment with atorvastatin normalized atrial superoxide in NOX2-Tg mice without affecting AF susceptibility. | Superoxides | cytochrome b-245, beta polypeptide | Mus musculus |
| 7 | Together these findings indicate that atrial NOX2-derived superoxide is more likely a biomarker of AF risk than a primary driver of AF development, and that NOX2 inhibition is unlikely to prevent the new-onset of AF. | Superoxides | cytochrome b-245, beta polypeptide | Mus musculus |