Pub. Date : 2021 Apr
PMID : 33482170
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | This study aimed to investigate the effects of abiraterone acetate and docetaxel on the expression of Notch1, Jagged1 and Hes1 in prostate cancer cell lines. | Abiraterone Acetate | notch receptor 1 | Homo sapiens |
| 2 | METHODS: In vitro effects of abiraterone acetate and docetaxel were examined on Notch1, Jagged1, and Hes1 expression in LNCaP and PC3 PCa cell lines by immunofluorescence, Western blot, and qRT-PCR. | Abiraterone Acetate | notch receptor 1 | Homo sapiens |
| 3 | RESULTS: We found that in the treatment of PC3 cells with abiraterone acetate, docetaxel, and their combination, only mRNA expressions of Notch1, Jagged1 and Hes1 were affected compared to control, but these expression differences were not observed in protein expression. | Abiraterone Acetate | notch receptor 1 | Homo sapiens |
| 4 | In LNCaP cells, abiraterone acetate and the combination groups reduced Notch1 protein expression. | Abiraterone Acetate | notch receptor 1 | Homo sapiens |