Pub. Date : 2021 Jan 21
PMID : 33479401
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Catechin and curcumin interact with S protein of SARS-CoV2 and ACE2 of human cell membrane: insights from computational studies. | Curcumin | surface glycoprotein | Severe acute respiratory syndrome coronavirus 2 |
| 2 | It is evident from the present computational study, that catechin and curcumin, not only exhibit strong binding affinity to viral S Protein and host receptor ACE2 but also to their complex (receptor-binding domain (RBD) of the spike protein of SARS-CoV2 and ACE2; RBD/ACE2-complex). | Curcumin | surface glycoprotein | Severe acute respiratory syndrome coronavirus 2 |
| 3 | It is evident from the present computational study, that catechin and curcumin, not only exhibit strong binding affinity to viral S Protein and host receptor ACE2 but also to their complex (receptor-binding domain (RBD) of the spike protein of SARS-CoV2 and ACE2; RBD/ACE2-complex). | Curcumin | surface glycoprotein | Severe acute respiratory syndrome coronavirus 2 |
| 4 | The binding affinity values of catechin and curcumin for the S protein, ACE2 and RBD/ACE2-complex are - 10.5 and - 7.9 kcal/mol; - 8.9 and - 7.8 kcal/mol; and - 9.1 and - 7.6 kcal/mol, respectively. | Curcumin | surface glycoprotein | Severe acute respiratory syndrome coronavirus 2 |
| 5 | Curcumin directly binds to the receptor binding domain (RBD) of viral S Protein. | Curcumin | surface glycoprotein | Severe acute respiratory syndrome coronavirus 2 |
| 6 | Protein-protein interaction studies in presence of curcumin or catechin also corroborate the above findings suggesting the efficacy of these two polyphenols in hindering the formation of S Protein-ACE2 complex. | Curcumin | surface glycoprotein | Severe acute respiratory syndrome coronavirus 2 |