Pub. Date : 2021 Jan 21
PMID : 33478532
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | HSP22 (HSPB8) positively regulates PGF2alpha-induced synthesis of interleukin-6 and vascular endothelial growth factor in osteoblasts. | Dinoprost | vascular endothelial growth factor A | Mus musculus |
| 2 | We previously demonstrated that prostaglandin F2alpha (PGF2alpha), a potent bone remodeling factor, induces the synthesis of interleukin-6 (IL-6) and vascular endothelial growth factor (VEGF) via p44/p42 mitogen-activated protein (MAP) kinase and p38 MAP kinase in osteoblast-like MC3T3-E1 cells. | Dinoprost | vascular endothelial growth factor A | Mus musculus |
| 3 | We previously demonstrated that prostaglandin F2alpha (PGF2alpha), a potent bone remodeling factor, induces the synthesis of interleukin-6 (IL-6) and vascular endothelial growth factor (VEGF) via p44/p42 mitogen-activated protein (MAP) kinase and p38 MAP kinase in osteoblast-like MC3T3-E1 cells. | Dinoprost | vascular endothelial growth factor A | Mus musculus |
| 4 | We previously demonstrated that prostaglandin F2alpha (PGF2alpha), a potent bone remodeling factor, induces the synthesis of interleukin-6 (IL-6) and vascular endothelial growth factor (VEGF) via p44/p42 mitogen-activated protein (MAP) kinase and p38 MAP kinase in osteoblast-like MC3T3-E1 cells. | Dinoprost | vascular endothelial growth factor A | Mus musculus |
| 5 | We previously demonstrated that prostaglandin F2alpha (PGF2alpha), a potent bone remodeling factor, induces the synthesis of interleukin-6 (IL-6) and vascular endothelial growth factor (VEGF) via p44/p42 mitogen-activated protein (MAP) kinase and p38 MAP kinase in osteoblast-like MC3T3-E1 cells. | Dinoprost | vascular endothelial growth factor A | Mus musculus |
| 6 | In the present study, we investigated whether HSP22 is implicated in the PGF2alpha-induced synthesis of IL-6 and VEGF and the mechanism of MC3T3-E1 cells. | Dinoprost | vascular endothelial growth factor A | Mus musculus |
| 7 | HSP22 knockdown also reduced the VEGF release by PGF2alpha. | Dinoprost | vascular endothelial growth factor A | Mus musculus |
| 8 | CONCLUSIONS: Our results strongly suggest that HSP22 acts as a positive regulator in the PGF2alpha-induced synthesis of IL-6 and VEGF in osteoblasts. | Dinoprost | vascular endothelial growth factor A | Mus musculus |