Title : Cross-talk between YAP and RAR-RXR Drives Expression of Stemness Genes to Promote 5-FU Resistance and Self-Renewal in Colorectal Cancer Cells.

Pub. Date : 2021 Apr

PMID : 33472949






2 Functional Relationships(s)
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1 Here we found that experimental YAP activation in 5FU-sensitive and 5FU-resistant HT29 CRC cells enhanced nuclear YAP localization and the transcript levels of the retinoic acid (RA) receptors RARalpha/gamma and RAR target genes CYP26A1, ALDH1A3 and LGR5 through RA Response Elements (RAREs). Tretinoin cytochrome P450 family 26 subfamily A member 1 Homo sapiens
2 Here we found that experimental YAP activation in 5FU-sensitive and 5FU-resistant HT29 CRC cells enhanced nuclear YAP localization and the transcript levels of the retinoic acid (RA) receptors RARalpha/gamma and RAR target genes CYP26A1, ALDH1A3 and LGR5 through RA Response Elements (RAREs). Tretinoin cytochrome P450 family 26 subfamily A member 1 Homo sapiens