Title : Mdm2 phosphorylation by Akt regulates the p53 response to oxidative stress to promote cell proliferation and tumorigenesis.

Pub. Date : 2021 Jan 26

PMID : 33468664






1 Functional Relationships(s)
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1 Akt phosphorylation of Mdm2 serine residue 183 increases nuclear Mdm2 stability, decreases p53 levels, and prevents senescence in primary cells exposed to reactive oxidative species (ROS). Serine thymoma viral proto-oncogene 1 Mus musculus