Title : 4-Octyl itaconate (4-OI) attenuates lipopolysaccharide-induced acute lung injury by suppressing PI3K/Akt/NF-κB signaling pathways in mice.

Pub. Date : 2021 Feb

PMID : 33456508






1 Functional Relationships(s)
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1 Further study demonstrated that a pharmacological inhibitor of the phosphoinositide 3-kinase (PI3K)-Akt pathway, LY294002, inhibited the expression of NF-kappaB p65 in the nuclear fraction and decreased the production of inflammatory cytokines. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one thymoma viral proto-oncogene 1 Mus musculus